@Article{ecn.2012.0297,
AUTHOR = {Federico Aranda, Silvia Perés Wingeyer, Sebastián Andrés Muñoz, Alberto Allievi, Alberto Orden, Rosana Trobo, Analía Alvarez, Alicia Eimon, Juan Carlos Barreira, Emilce Schneeberger, Judith Sarano, Julio Hofman, Gabriela de Larrañaga},
TITLE = {The -2518 A/G polymorphism in the monocyte chemoattractant protein 1 gene is associated with the risk of developing systemic lupus erythematosus in Argentinean patients: a multicenter study},
JOURNAL = {European Cytokine Network},
VOLUME = {23},
YEAR = {2012},
NUMBER = {1},
PAGES = {7--11},
URL = {http://www.techscience.com/ECN/v23n1/65756},
ISSN = {1952-4005},
ABSTRACT = {Systemic lupus erythematosus (SLE) is a systemic, autoimmune disorder. Monocyte chemoattractant protein 1
(MCP-1), a chemokine involved in the recruitment and migration of monocytes/macrophages, has been shown to
be increased in the plasma of SLE patients. The aim of our study was to evaluate the possible association of the
polymorphism -2518 of the MCP-1 gene with the risk of developing SLE, manifesting lupus nephritis (LN) and
with other clinical features of SLE in an Argentinean population. A group of 171 SLE patients and 120 control
subjects were examined. Genotypic and allelic frequencies of theMCP-1 -2518 A/G polymorphism showed significant
differences between the SLE and the control groups (p=0.001 and p=0.01, respectively). However, the polymorphism
showed no association with LN or with the other clinical variables studied. Our results suggest that the presence of the
MCP-1 -2518 A/G polymorphism might be a risk factor for developing SLE in genetically predisposed individuals,
but it does not seem to have a role in the evolution of the disease in the Argentinean population.},
DOI = {10.1684/ecn.2012.0297}
}