@Article{ecn.2012.0300,
AUTHOR = {Eva Pfeifer, Johannes Polz, Daniela N. Männel, Sven Mostböck},
TITLE = {Inflammation augments the development of experimental glomerulonephritis by accelerating proteinuria and enhancing mortality},
JOURNAL = {European Cytokine Network},
VOLUME = {23},
YEAR = {2012},
NUMBER = {1},
PAGES = {12--14},
URL = {http://www.techscience.com/ECN/v23n1/65757},
ISSN = {1952-4005},
ABSTRACT = {Proteinuria represents a parameter for a damaged filtration capacity of the kidney. We investigated
how inflammation influences the development of experimental, immune complex-mediated glomerulonephritis by
monitoring proteinuria.Mice pre-treated with LPS or TNF, one day before induction of glomerulonephritis, excreted
high levels of protein in the urine immediately after the induction of glomerulonephritis, in contrast to non-treated
mice where proteinuria increased steadily after day 3. Protein levels in the urine of pre-treated mice remained
elevated over the 15-day observation time. The severity of proteinuria at later times correlated with the degree
of tissue pathology and mortality in individual mice. Pre-treatment with inflammatory agents accelerated the
development of proteinuria and induced more severe kidney damage.},
DOI = {10.1684/ecn.2012.0300}
}