@Article{ecn.2012.0304,
AUTHOR = {Nilgün Köksal, Bülent Kayık, Merih Çetinkaya, Hilal Özkan, Ferah Budak, Şebnem Kılıç, Yakup Canıtez, Barbaros Oral},
TITLE = {Value of serum and bronchoalveolar fluid lavage pro- and anti-inflammatory cytokine levels for predicting bronchopulmonary dysplasia in premature infants},
JOURNAL = {European Cytokine Network},
VOLUME = {23},
YEAR = {2012},
NUMBER = {2},
PAGES = {29--35},
URL = {http://www.techscience.com/ECN/v23n2/65749},
ISSN = {1952-4005},
ABSTRACT = {Objective: The aim of this study was to determine the value of pro- and anti-inflammatory cytokine
levels in both blood and tracheal aspirate (TA) samples that were obtained within 24 h after birth for predicting
bronchopulmonary dysplasia (BPD) development in premature infants. Material and methods: Premature infants,
who were born before 32 weeks of gestation, weighing less than 1,500 g, and admitted with respiratory distress
between September 2009 and December 2010, were enrolled. Tracheal aspirate samples and serum were obtained
from all infants on the first day of admittance for evaluation of pro- and anti-inflammatory cytokine levels using
ELISA. Results: The study included 102 premature babies of whom 31 (30%) had BPD diagnosed in the follow-up.
Mild, moderate and severe BPD was diagnosed in 10 (32%), 14 (45%) and seven (23%) infants, respectively. Both
serum and TA sample pro-inflammatory cytokine (TNF-α, IL-1β, IL-6) levels were significantly higher, and antiinflammatory
cytokine (IL-10) levels were significantly lower in infants who developed BPD compared with those
who had no BPD. No significant differences were detected in either serum or TA sample pro- and anti-inflammatory
cytokine concentrations in preterm infants with BPD in terms of BPD severity. Cut-off values of both serum and TA
sample pro- and anti-inflammatory cytokine concentrations for predicting BPD were also determined. Conclusion:
It is suggested that higher serum and TA pro-inflammatory cytokine (TNF-α, IL-1β, IL-6) concentrations, along
with lower anti-inflammatory cytokine (IL-10) concentrations, might be used for predicting the development of
BPD in premature infants with respiratory distress at birth.},
DOI = {10.1684/ecn.2012.0304}
}