@Article{ecn.2014.0346,
AUTHOR = {Victoria Perna, Antonio Pérez-Pérez, Patricia Fernández-Riejos, Juan Polo-Padillo, Nínive Batista, Angel Domínguez-Castellano, Víctor Sánchez-Margalet},
TITLE = {Effective treatment of pulmonary tuberculosis restores plasma leptin levels},
JOURNAL = {European Cytokine Network},
VOLUME = {24},
YEAR = {2013},
NUMBER = {4},
PAGES = {157--161},
URL = {http://www.techscience.com/ECN/v24n4/65627},
ISSN = {1952-4005},
ABSTRACT = {An impaired immune response in tuberculosis patients seems to be related to weight loss that coexists
with an immunoendocrine imbalance. Thus, wasting is well-recognised as a prominent feature of tuberculosis (TB),
which may not be reversed even after six months of treatment. Adipokines may play a role in the immune response
to <i>M. tuberculosis</i>, and TB may impair the expression of inflammatory adipokines, such as leptin. We aimed to
study patients with pulmonary TB before and six months after treatment, by measuring plasma leptin, soluble
leptin receptor and adiponectin, weight and body mass index. Nineteen patients with a diagnosis of pulmonary
TB were included in the study. Blood samples were obtained before and six months after treatment, to measure
plasma adipokine levels. We found an increase in plasma leptin levels after treatment (p<0.05). Even though BMI
also increased, the extent was not enough to account for the changes in the leptin levels. On the other hand, plasma
soluble leptin receptor and adiponectin levels did not change significantly after treatment.In conclusion, these
results suggest that active TB infection may affect the expression of leptin, in addition to the wasting that may occur
in these patients, and that effective TB treatment increases circulating leptin levels, probably restoring normal
immunological competence.},
DOI = {10.1684/ecn.2014.0346}
}