@Article{ecn.2014.0350,
AUTHOR = {Gholamreza Daryabor, Mahdi Mahmoudi, Ahmadreza Jamshidi, Keramat Nourijelyani, Aliakbar Amirzargar, Nooshin Ahmadzadeh, Elham Farhadi, Mohammad Hossein Nicknam},
TITLE = {Determination of IL-23 receptor gene polymorphism in Iranian patients with ankylosing spondylitis},
JOURNAL = {European Cytokine Network},
VOLUME = {25},
YEAR = {2014},
NUMBER = {1},
PAGES = {24--29},
URL = {http://www.techscience.com/ECN/v25n1/65565},
ISSN = {1952-4005},
ABSTRACT = {Introduction: The result of recent genome-wide association studies revealed that, in addition to HLAB27,
a few non-HLAgenes are associated with susceptibility to ankylosing spondylitis (AS) in Caucasian populations.
According to these studies, IL-23R is one of the genes that is associated with AS. In this study, we evaluated five
important single nucleotide polymorphisms (SNPs) of the IL-23R gene which confers susceptibility to AS, and its
effects on the severity of the disease in HLA-B27 positive and negative patients and several subtypes of HLA-B27.
Materials and methods: The study population consisted of 294 AS patients and 352 age-, sex-, and ethnicity-matched
healthy controls. All patients were examined by rheumatologists, and met modified, New York criteria for the disease.
Five SNPs (rs1004819, rs11209032, rs1495965, rs11465804, and rs1004819) of the IL-23R gene were genotyped using
the Real-Time PCR TaqMan genotyping method. Results: We found that only rs1004819 has a significant association
with AS, and that the remaining four SNP alleles are not associated with AS. Also, there was no association between
these five polymorphisms and BASDAI, BASFI, and BASMI indices. Two haplotypes, ACGAT and ACGAG, were
found to be associated with the heritability of AS. In addition, two significant, protective diplotypes (D8, <img src="https://www.techscience.com/files/ecn/ecn24.png" width="40px">;
and D9, <img src="https://www.techscience.com/files/ecn/ecn24-1.png" width="40px"> ) were discovered. Conclusion: This study supported our previous findings regarding the differences
between the genetic patterns of AS in Iranian patients compared with those in other parts of the world.},
DOI = {10.1684/ecn.2014.0350}
}