@Article{ecn.2014.0352,
AUTHOR = {Vahid Ziaee, Fatemeh Tahghighi, Mohammad Hassan Moradinejad, Sara Harsini, Maryam Mahmoudi, Arezou Rezaei, Samaneh Soltani, Maryam Sadr, Yahya Aghighi, Nima Rezaei},
TITLE = {Interleukin-6, interleukin-1 gene cluster and interleukin-1 receptor polymorphisms in Iranian patients with juvenile systemic lupus erythematosus},
JOURNAL = {European Cytokine Network},
VOLUME = {25},
YEAR = {2014},
NUMBER = {2},
PAGES = {35--40},
URL = {http://www.techscience.com/ECN/v25n2/65561},
ISSN = {1952-4005},
ABSTRACT = {Background: Juvenile systemic lupus erythematosus (JSLE) is a polygenic, autoimmune disorder of
unknown origin. As proinflammatory cytokines, including interleukin-6 (IL-6) and the interleukin-1 (IL-1) family,
seem to contribute to the pathogenesis of JSLE, this investigation was performed to assess the associations of
particular single nucleotide polymorphisms (SNPs) of IL-6 and IL-1 genes in a case-control study. Methods: Fifty
nine JSLE cases were recruited for this study as the patient group, and were compared against 140 healthy, unrelated,
control subjects. Using the polymerase chain reaction with the sequence-specific primer method, genotyping was
carried out for the IL-6 gene at positions -174 and nt565, as well as the IL-1 gene at position -889, the IL-1β gene
at positions -511 and +3962, the interleukin-1 receptor (IL-1R) gene at position Pst-I 1970, and the interleukin-1
receptor antagonist (IL-1Ra) gene at position Mspa-I 11100. Results: Results of the analyzed data revealed a
remarkable, positive association for the promoter sequence of the IL-1β gene at position -511 for T/T in the patient
group compared with healthy controls (P value, 0.03). Furthermore, a significant negative association was found
between the T/C genotype at the same position on the IL-1β gene in juvenile SLE (P value, 0.03). Conclusions:
cytokine gene polymorphisms might play a role in the pathophysiology of JSLE. Particular IL-1 gene variants
could affect individual susceptibility to JSLE.},
DOI = {10.1684/ecn.2014.0352}
}