@Article{ecn.2014.0354,
AUTHOR = {Bartosz Hudzik, Aleksander Danikiewicz, Janusz Szkodzinski, Lech Polonski, Barbara Zubelewicz-Szkodzinska},
TITLE = {Pentraxin-3 concentrations in stable coronary artery disease depend on the clinical presentation},
JOURNAL = {European Cytokine Network},
VOLUME = {25},
YEAR = {2014},
NUMBER = {3},
PAGES = {41--45},
URL = {http://www.techscience.com/ECN/v25n3/65556},
ISSN = {1952-4005},
ABSTRACT = {Introduction: Pentraxin-3 (PTX3) is an acute-phase reactant that shares structural and functional
homology with C-reactive protein (CRP). However, unlike CRP, which is synthesized mainly in the liver, PTX3 is
produced at the site of inflammation. It has been suggested that PTX3 plays the same role in the periphery that CRP
does in circulation. PTX3 may represent a rapid marker of local inflammation. Methods: Fifty-one patients with
stable coronary artery disease (CAD) were enrolled. Blood samples were collected on admission. Plasma concentration
of PTX3 and high-sensitivity CRP (hsCRP) were determined. Results: Median PTX3 concentration was
0.92 μmol/L (0.58–1.40). Median hsCRP concentration was 0.90 mg/L (0.75–1.10). There was a positive correlation
between PTX3 and total cholesterol (R = 0.34; P = 0.01), PTX3 and LDL cholesterol (R = 0.35; P = 0.01), and
PTX3 and hsCRP (R = 0.46; P = 0.0005). We found no correlation between hsCRP and all laboratory parameters.
We found higher PTX3 concentrations in patients with Canadian Cardiovascular Society (CCS) functional class 3
(compared to CCS functional class 2) and in patients taking nitrates. Lower PTX3 concentrations were reported
in patients taking calcium channel blockers (amlodipine). hsCRP concentrations remained similar among these
subgroups of patients. Conclusions: PTX3 is a marker of clinically more advanced CAD (CCS2 vs CCS3; nitrates
vs no nitrates). PTX3 is also associated with other cardiovascular risk factors (total cholesterol, LDL cholesterol,
and hsCRP). PTX3 may be a potential early marker of cardiovascular risk before the increase of systemic markers
like hsCRP.},
DOI = {10.1684/ecn.2014.0354}
}