@Article{ecn.2014.0355,
AUTHOR = {Marzena Dworacka, Ewa Krzyz̀agórska, Saule Iskakova, Yerbol Bekmukhambetov, Olzhas Urazayev, Grzegorz Dworacki},
TITLE = {Increased circulating RANTES in type 2 diabetes},
JOURNAL = {European Cytokine Network},
VOLUME = {25},
YEAR = {2014},
NUMBER = {3},
PAGES = {46--51},
URL = {http://www.techscience.com/ECN/v25n3/65557},
ISSN = {1952-4005},
ABSTRACT = {Aim:The pro-atherogenic role of RANTES, a chemokine expressing pleiotropic activities, in the course
of type 2 diabetes-related atherosclerosis has been well documented. However, it is not known which of the diabetes-related
factors primarily influence serum RANTES levels in patients with type 2 diabetes. Our aim was to investigate
relationships between several factors known to be related to an increased risk of atherosclerosis and serum RANTES
levels in type 2 diabetic patients. Methods: A total of 168 subjects were examined, which included 138 patients
with type 2 diabetes and 30 non-diabetic controls. Measurements of venous, fasting, plasma glucose, HbA1c, lipid
profile, 1,5-anhydro-D-glucitol (1,5-AG) plasma levels, homocysteine and the fasting, serum C-peptide levels were
performed. Serum concentrations of RANTES were assayed using BDTM Cytometric Bead Array tests. Peripheral
insulin resistance was expressed according to a new index defined by Ohkura et al. Results: RANTES levels in
type 2 diabetic patients correlated with 1,5-AG, fasting glycaemia, HbA1c and the Ohkura index. Multivariate
regression analysis was performed taking into consideration several factors related to the inflammatory process
and atherosclerosis, namely the patient’s age, diabetes duration, waist circumference, 1,5-AG, HbA1c, lipid profile
parameters, serum homocysteine levels and Ohkura index, as independent variables potentially influencing serum
RANTES levels in type 2 diabetic patients. It is shown that RANTES concentrations in the serum is primarily
dependent upon 1,5-AG plasma levels. Conclusion: Our results suggest that increased serum levels of RANTES in
type 2 diabetic patients are closely related to postprandial (acute) hyperglycaemia.},
DOI = {10.1684/ecn.2014.0355}
}