@Article{ecn.2015.0363,
AUTHOR = {Dorota Mańkowska-Wierzbicka, Ewelina Swora-Cwynar, Barbara Poniedziałek, Zygmunt Adamski, Agnieszka Dobrowolska, Jacek Karczewski},
TITLE = {Usefulness of selected laboratory markers in ulcerative colitis},
JOURNAL = {European Cytokine Network},
VOLUME = {26},
YEAR = {2015},
NUMBER = {2},
PAGES = {26--37},
URL = {http://www.techscience.com/ECN/v26n2/65548},
ISSN = {1952-4005},
ABSTRACT = {Introduction: This study aimed to compare the accuracy of selected laboratory markers in assessing
disease activity in patients with ulcerative colitis (UC). The analysis included serum IL-2, IL-4, IL-6, IL-10, IL-17,
TNF-α, IFN-γ, hsCRP, peripheral regulatory T cells, as well as fecal calprotectin and lactoferrin. Patients and
methods: A group of 45 adults with UC was enrolled in the study. Disease activity was assessed using the Mayo
endoscopic index, while for clinical activity scoring, the Clinical Activity Index (CAI) was used. Concentrations of
markers investigated were estimated by means of flow cytometry and enzyme-linked immunosorbent assays: the
results were correlated with both indices. Results: The study demonstrated that both fecal markers, i.e. calprotectin
(r = 0.880, P<0.001) and lactoferrin (r = 0.799, P<0.001) correlated closely with the Mayo endoscopic score, and
might be used to evaluate the severity of UC in the clinical setting. The correlation of these markers with CAI was
also significant, with r = 0.831 for calprotectin (P<0.001) and r = 0.672 for lactoferrin (P<0.05). As for the other
markers investigated, only IL-6 (r = 0.598, P<0.001), IL-17A (r = 0.587, P<0.005), and TNF-α (r = 0.701, P<0.001)
correlated closely with the Mayo endoscopic index. The correlation of the markers with CAI was also significant,
though weaker, with r = 0.525 for IL-6 (P<0.001), r = 0.587 for IL-17A (P<0.05), and r = 0.624 for TNF-α (P<0.001).
Discussion: Despite the fact, that UC is generally considered to be an IL-13-driven, Th2-like type of disease, markers
of inflammation such as serum interleukin (IL)-6, IL-17, TNF-α, fecal calprotectin and lactoferrin might be useful
in assessing disease activity.},
DOI = {10.1684/ecn.2015.0363}
}