@Article{ecn.2016.0371,
AUTHOR = {Pablo Ramon Gualberto Cardoso, Emerson Vasconcelos de Andrade Lima, Mariana Modesto de Andrade Lima, Moacyr Jesus Barreto de Melo Rêgo, Claudia Diniz Lopes Marques, Ivan da Rocha Pitta, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta},
TITLE = {Clinical and cytokine profile evaluation in Northeast Brazilian psoriasis plaque-type patients},
JOURNAL = {European Cytokine Network},
VOLUME = {27},
YEAR = {2016},
NUMBER = {1},
PAGES = {1--5},
URL = {http://www.techscience.com/ECN/v27n1/65542},
ISSN = {1952-4005},
ABSTRACT = {Objective and Design: Psoriasis is a common, enigmatic, and recurrent disease. The precise etiology
and pathogenesis of psoriasis are still unclear. Psoriasis has been treated as an inflammatory disorder related to an
underlying Th1/Th17-dominated immune response. Interleukins are involved in the development of psoriasis lesions
through Th-17-associated inflammation. Th1 and Th17 cytokines are found in skin lesions and in the peripheral
blood of psoriasis patients. We sought to analyze serum levels of IL-1-β, IL-8, IL-9, IL-27, IL-29, IL-35, IFN-γ, TNF
and TGF-β in patients with psoriasis and healthy control volunteers. Material: Blood samples were collected from
fifty-three patients with psoriasis and thirty-five healthy controls. Methods: Serum cytokines concentrations were
determined using an enzyme-linked immunosorbent assay. Results: Serum IL-8, IL-9, IL-27, IL-29 and TNF levels
were statistically significant in psoriasis patients. Detectable serum IL-9 levels were found in 47 patients of the 53 in
the psoriasis group. Conclusions: Interleukins-8, 27, 29 and TNF levels measured in the serum of psoriasis patients
were slightly elevated as compared to healthy controls in a weakly significant way. On the other hand, there were
highly significant differences in IL-9 levels between the two groups.},
DOI = {10.1684/ecn.2016.0371}
}