TY  - EJOU
AU  - Cardoso, Pablo Ramon Gualberto 
AU  - Lima, Emerson Vasconcelos de Andrade 
AU  - Lima, Mariana Modesto de Andrade 
AU  - Rêgo, Moacyr Jesus Barreto de Melo 
AU  - Marques, Claudia Diniz Lopes 
AU  - Pitta, Ivan da Rocha 
AU  - Duarte, Angela Luzia Branco Pinto 
AU  - Pitta, Maira Galdino da Rocha 

TI  - Clinical and cytokine profile evaluation in Northeast Brazilian psoriasis plaque-type patients
T2  - European Cytokine Network

PY  - 2016
VL  - 27
IS  - 1
SN  - 1952-4005

AB  - Objective and Design: Psoriasis is a common, enigmatic, and recurrent disease. The precise etiology
and pathogenesis of psoriasis are still unclear. Psoriasis has been treated as an inflammatory disorder related to an
underlying Th1/Th17-dominated immune response. Interleukins are involved in the development of psoriasis lesions
through Th-17-associated inflammation. Th1 and Th17 cytokines are found in skin lesions and in the peripheral
blood of psoriasis patients. We sought to analyze serum levels of IL-1-β, IL-8, IL-9, IL-27, IL-29, IL-35, IFN-γ, TNF
and TGF-β in patients with psoriasis and healthy control volunteers. Material: Blood samples were collected from
fifty-three patients with psoriasis and thirty-five healthy controls. Methods: Serum cytokines concentrations were
determined using an enzyme-linked immunosorbent assay. Results: Serum IL-8, IL-9, IL-27, IL-29 and TNF levels
were statistically significant in psoriasis patients. Detectable serum IL-9 levels were found in 47 patients of the 53 in
the psoriasis group. Conclusions: Interleukins-8, 27, 29 and TNF levels measured in the serum of psoriasis patients
were slightly elevated as compared to healthy controls in a weakly significant way. On the other hand, there were
highly significant differences in IL-9 levels between the two groups.
KW  - psoriasis
KW  -  IL-8
KW  -  IL-9
KW  -  IL-27
KW  -  IL-29
KW  -  Brazilian Patients

DO  - 10.1684/ecn.2016.0371