@Article{ecn.2016.0375,
AUTHOR = {Shahriar Dabiri, Ashraf Kariminik, Derek Kennedy},
TITLE = {The role of CXCR3 and its ligands in renal transplant outcome},
JOURNAL = {European Cytokine Network},
VOLUME = {27},
YEAR = {2016},
NUMBER = {2},
PAGES = {16--22},
URL = {http://www.techscience.com/ECN/v27n2/65537},
ISSN = {1952-4005},
ABSTRACT = {Chemokines and their corresponding receptors serve as pro-inflammatory and migratory signals
for immune cells. CXCR3 and its corresponding ligands, CXCL9, CXCL10 and CXCL11, participate in the
induction of immune responses against several foreign antigens. Numerous cells, including macrophages, NK
cells and T lymphocytes, express CXCR3 and thus, expression of the receptor and its ligands can induce activity
of these important immune cells against foreign antigens, including allogeneic grafts. Several parameters
of the immune system participate in the induction and stimulation of powerful immune responses against allogeneic
grafts. A thorough understanding of the parameters that regulate these responses can provide insights into
new methods for immunotherapy during organ transplantation. The aim of this review is to address the most
recent information regarding the roles played by CXCR3 and its corresponding ligands in the outcome of renal
transplantation.},
DOI = {10.1684/ecn.2016.0375}
}