@Article{ecn.2017.0394,
AUTHOR = {Magali Garcia, Michel Wehbe, Nicolas Lévêque, Charles Bodet},
TITLE = {Skin innate immune response to flaviviral infection},
JOURNAL = {European Cytokine Network},
VOLUME = {28},
YEAR = {2017},
NUMBER = {2},
PAGES = {41--51},
URL = {http://www.techscience.com/ECN/v28n2/65518},
ISSN = {1952-4005},
ABSTRACT = {Skin is a complex organ and the largest interface of the human body exposed to numerous stress
and pathogens. Skin is composed of different cell types that together perform essential functions such as pathogen
sensing, barrier maintenance and immunity, at once providing the first line of defense against microbial infections
and ensuring skin homeostasis. Being inoculated directly through the epidermis and the dermis during a vector
blood meal, emerging Dengue, Zika and West Nile mosquito-borne viruses lead to the initiation of the innate immune
response in resident skin cells and to the activation of dendritic cells, which migrate to the draining lymph node
to elicit an adaptive response. This literature review aims to describe the inflammatory response and the innate
immune signalization pathways involved in human skin cells during Dengue, Zika and West Nile virus infections.},
DOI = {10.1684/ecn.2017.0394}
}