@Article{ecn.2017.0395,
AUTHOR = {Maria Giovanna Vilia, Marta Tocchetti, Eleonora Fonte, Ilenia Sana, Marta Muzio},
TITLE = {Characterization of a long isoform of IL-1R8 (TIR8/SIGIRR)},
JOURNAL = {European Cytokine Network},
VOLUME = {28},
YEAR = {2017},
NUMBER = {2},
PAGES = {63--69},
URL = {http://www.techscience.com/ECN/v28n2/65520},
ISSN = {1952-4005},
ABSTRACT = {IL-1R8, also known as SIGIRR or TIR8, is a trans-membrane protein belonging to the IL-1 receptor
family. The human gene includes ten exons, and alternative splicing can result in different isoforms. We, herein,
characterized a longer isoform of IL-1R8 containing an in-frame additional sequence between the TIR domain and
the C-terminal portion of the protein. IL-1R8 Long (IL-1R8L1) mRNA was specifically expressed and regulated in
distinct cell lines, in a manner similar to the classic isoform. Overexpression of IL-1R8L1 resulted in the production
of a corresponding protein that showed a pattern of cell localization similar to the classic isoform. An antibody
directed against an IL-1R8L1 specific peptide, detected this novel isoform in different cell lines and tissues where
this protein may complement the anti-inflammatory functions of classic IL-1R8.},
DOI = {10.1684/ecn.2017.0395}
}