@Article{ecn.2018.0404,
AUTHOR = {Sara Harsini, Amene Saghazadeh, Saharnaz Nedjat, Nima Rezaei},
TITLE = {Associations between interleukin-10 polymorphisms and susceptibility to juvenile idiopathic arthritis: a systematic review and meta-analysis},
JOURNAL = {European Cytokine Network},
VOLUME = {29},
YEAR = {2018},
NUMBER = {1},
PAGES = {16--26},
URL = {http://www.techscience.com/ECN/v29n1/65408},
ISSN = {1952-4005},
ABSTRACT = {Background: Cytokine genes, including interleukin-10 (IL-10), are known to play important roles in the
pathogenesis of juvenile idiopathic arthritis (JIA). This study aims to determine whether the IL-10 polymorphisms
confer susceptibility to JIA. Methods: A meta-analysis was performed on the associations between the IL-10 -1082
G/A, -592 C/A, and -819 C/T polymorphisms and JIA. A total number of 7 studies involving 1,785 patients and
6,142 controls were considered in the meta-analysis. Results: Meta-analysis of the IL-10 -592 C/A and -819 C/T
polymorphisms showed no association with JIA in the study participants, or in Caucasian or Middle Eastern
participants. Meta-analysis of the IL-10 -1082 A allele in all study participants, Caucasian and Middle Eastern,
showed significant associations with RA (overall ORs were 1.17, 1.15, and 1.41, respectively). Meta-analysis of the
AA versus GG genotype of the IL-10 -1082 G/A polymorphism revealed significant associations with JIA (OR = 3.66,
95% CI = 1.44-9.29, P = 0.006) in participants from Middle Eastern countries. Additionally, meta-analysis of the GG
versus AA+GA genotypes of the IL-10 -1082 G/A polymorphism revealed the GG genotype as the protective factor
against JIA in the Middle Eastern subgroup (OR = 0.44, 95% CI = 0.20-0.94, P = 0,04). Moreover, meta-analysis
of the IL-10 -1082 A allele in 4 studies on Hardy-Weinberg equilibrium showed a significant association with JIA
(OR = 1.17, 95% CI = 1.07-1.28, P = 0.0009). No association was found between the IL-10 (-1082, -819, -592) ACC,
ATA, and GCC haplotypes and JIA. Conclusions: These results suggest that the IL-10 -1082 G/A polymorphism
confers susceptibility to JIA.},
DOI = {10.1684/ecn.2018.0404}
}