@Article{ecn.2018.0405,
AUTHOR = {Mahmoud Al-Azab, Jing Wei, Xunli Ouyang, Abdalkhalig Elkhider, Williams Walana, Xiaotong Sun, Yawei Tang, Bing Wang, Xia Li},
TITLE = {TL1A mediates fibroblast-like synoviocytes migration and Indian Hedgehog signaling pathway via TNFR2 in patients with rheumatoid arthritis},
JOURNAL = {European Cytokine Network},
VOLUME = {29},
YEAR = {2018},
NUMBER = {1},
PAGES = {27--35},
URL = {http://www.techscience.com/ECN/v29n1/65409},
ISSN = {1952-4005},
ABSTRACT = {Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joints inflammation.
One of the aggressive characteristics of RA fibroblast-like synoviocytes (FLS) is the tendency for migration in the
local environment, which plays a central role in the RA pathogenesis. Tumor Necrosis Factor (TNF)-like cytokine
1A (TL1A) is a member of TNF superfamily, which has a role in autoimmunity and influences the RA-FLS behavior
through TNF receptor 2 (TNFR2). We investigated the effect of TNF-like cytokine 1A (TL1A) on RA-FLS migration
using patients’ samples. Specifically, we examined the hedgehog signaling pathway which is a key regulator in
chondrocyte growth and differentiation. We found that TL1A increased significantly the hedgehog homologue
Indian hedgehog (IHH) and its receptor Patched 1, 2 (PTCH 1, 2) in RA-FLS. In addition, TL1A-stimulated RAFLS
promoted significantly IHH protein expression. However, both mRNA and protein levels decreased substantially
after blocking TL1A with TNFR2 antagonist. The migratory property of RA-FLS was enhanced after stimulation
of RA-FLS with TL1A, but was compromised following TL1A blockage. In conclusion, our study has revealed that
TL1A modulated RA-FLS migration and Indian hedgehog signaling pathway using TNFR2.},
DOI = {10.1684/ecn.2018.0405}
}