@Article{ecn.2018.0408,
AUTHOR = {Faruk Tas, Senem Karabulut, Kayhan Erturk, Derya Duranyildiz},
TITLE = {Clinical significance of serum leptin level in patients with gastric cancer},
JOURNAL = {European Cytokine Network},
VOLUME = {29},
YEAR = {2018},
NUMBER = {2},
PAGES = {52--58},
URL = {http://www.techscience.com/ECN/v29n2/65405},
ISSN = {1952-4005},
ABSTRACT = {Leptin may support the proliferation and hinder the apoptosis of tumor cells. Although leptin expression
has been studied in several human tumors, its potential clinical significance remains uncertain in patients with
gastric carcinoma. Furthermore, the majority of available findings have been determined from preclinical studies
using stomach carcinoma tissue section and, to date, few studies have evaluated the clinical significance of leptin
in the serum or plasma of gastric carcinoma patients. In the current study, the serum concentration of soluble
leptin was assessed in gastric carcinoma patients, and its contributions to the clinical parameters and prognosis of
patients were determined. A total of 63 pathologically confirmed gastric cancer patients and 30 healthy subjects
were enrolled in the study and circulating leptin levels in the serum of all subjects were determined by ELISA.
The serum leptin concentrations were significantly lower in the gastric cancer patients compared with the healthy
control group (P = 0.009). In the gastric cancer patients, the clinical features of patient age, sex, lesion localization,
histopathology, pathological grade, stage of disease, and serum tumor markers including lactate dehydrogenase,
carcinoembryonic antigen, and carbohydrate antigen 19-9 were not correlated with serum leptin concentration.
Furthermore, no association was observed between serum leptin concentration and responsiveness to chemotherapy
(P = 0.51), and leptin level had no apparent prognostic role in clinical outcome (P = 0.57). In conclusion, although
it was not predictive or prognostic, serum leptin level may be a valuable diagnostic indicator in patients with gastric
carcinoma.},
DOI = {10.1684/ecn.2018.0408}
}