@Article{ecn.2019.0422,
AUTHOR = {Chul Soo Park, Hye Young Moon, Sangbin Han, Jin Young Chon, Min Suk Chae, Sang Hyun Hong, Jong Ho Choi, Hyun Sik Chung},
TITLE = {Ischemic time of graft liver forces Th1-to-Th2 activity toward Th1 activity in patients who underwent living donor liver transplantation},
JOURNAL = {European Cytokine Network},
VOLUME = {30},
YEAR = {2019},
NUMBER = {1},
PAGES = {23--28},
URL = {http://www.techscience.com/ECN/v30n1/65399},
ISSN = {1952-4005},
ABSTRACT = {Recipient’s immune responses are an important factor in allograft survival in transplantation. Cytokines
are reflected with immune responses. In the present study, we aimed to evaluate potential affecting factors of liver
allograft survival and their possible correlation with seroum cytokine levels in living donor liver transplantation
(LDLT). One hundred and seventy-one adult patients’ data were collected retrospectively. Five cytokines were
collected: interferon (IFN)-γ, interleukin (IL)-2, IL-10, IL-6, and IL-17. Ischemic time of liver grafts was divided into
two periods: cold and warm ischemic times (CIT and WIT, respectively). CIT had no statically significant correlation,
but WIT showed a significant correlation with IFN-γ, IL-2, and IL-17 serum levels (r = 0.0252, 0.282, 0.178,
respectively; P < 0.05). WIT was dichotomized as T1 (<22 min), T2 (22-70 min), and T3 (>70 min). IFN-γ was
significantly increased in T2 and T3 as compared to T1. IL-6 was in T3 compared to T1 and T2. IL-17 was in T3
compared to T1. For the Th1-to-Th2 ratio, IFN-γ/IL-10, IFN-γ/IL-6, and IL-2/IL-10 were significantly different in T2
and T3 as compared to T1, and also in T3 as compared to T2. Th1 cell activities were enhanced with increased WIT. In
conclusion, the longer WIT (>70 min) in LDLT is more likely to induce immunological reactions of recipients by
leading to a deleterious cytokine balances in favor of an reinforced production of Th1 cytokines.},
DOI = {10.1684/ecn.2019.0422}
}