@Article{ecn.2019.0423,
AUTHOR = {Ayse Ekin Kara, Gurhan Guney, Aytekin Tokmak, Gulnur Ozaksit},
TITLE = {The role of inflammatory markers hs-CRP, sialic acid, and IL-6 in the pathogenesis of preeclampsia and intrauterine growth restriction},
JOURNAL = {European Cytokine Network},
VOLUME = {30},
YEAR = {2019},
NUMBER = {1},
PAGES = {29--33},
URL = {http://www.techscience.com/ECN/v30n1/65400},
ISSN = {1952-4005},
ABSTRACT = {Objective: The aim of our study was to evaluate serum high-sensitivity C-Reactive Protein (hs-CRP),
sialic acid (SA), and interleukin-6 (IL-6) levels in pregnancies complicated with preeclampsia (PE) and intrauterine
growth restriction (IUGR) and to compare with healthy pregnancies. Materials and Methods: This study was conducted
at a tertiary-level maternity hospital with 80 pregnant women. Fasting blood samples were taken from 44 consecutive
women with pregnancies complicated by PE (n: 20) and IUGR (n: 24), and 36 were from normal pregnancies. Serum hs-CRP,
SA, and IL-6 concentrations were measured in all participants. Results: Serum mean hs-CRP, SA, and IL-6
levels were higher in the PE and IUGR group when compared with the control group, but this difference was statistically
insignificant (P>0.05). No significant correlation was observed between these inflammatory markers (P>0.05).
Conclusion: The serum levels of hs-CRP, SA, and IL-6 were not elevated in pregnancies complicated with PE and
IUGR compared with normal pregnancies. Since pregnancy is already a process with inflammation, fluctuations in some
markers related to inflammation may be masked by the gestation itself. A local subclinical inflammation may have a
role in the pathogenesis of PE and IUGR rather than systemic inflammation.},
DOI = {10.1684/ecn.2019.0423}
}