TY  - EJOU
AU  - Sibaii, Hiba 
AU  - El-Zayat, Salwa Refat 
AU  - Khalil, Mona 

TI  - When wrinkles appear on the immune system can it be reversed?
T2  - European Cytokine Network

PY  - 2020
VL  - 31
IS  - 1
SN  - 1952-4005

AB  - During aging, physiological and physical frailty occur, which is accompanied by a decline in adaptive and
innate immunity, termed ‘immunosenescence’ characterized by marked changes in the composition, function, and
competence of the human immune system. Moreover, the capabilities of the immune system to defend the human body
against infections, to detect and destruct malignant or autoreactive cells decline, resulting in an increase in the
susceptibility to infection, development of cancer, as well as autoimmune disorders. The study of age-related changes in
immune function is an important area of investigation. In this review, the function of the immune system during aging, as
well as the different ways to rejuvenate the aging immune system, is explored, as medical intervention, balanced
nutrition, and a healthy life style will be discussed.
KW  - immunosenescence
KW  -  adaptive immunity
KW  -  innate immunity
KW  -  rejuvenation

DO  - 10.1684/ecn.2020.0441