@Article{ecn.2020.0443,
AUTHOR = {Gurhan Guney, Mine Islimye Taskin, Aytekin Tokmak},
TITLE = {Increase of circulating inflammatory molecules in preeclampsia, an update},
JOURNAL = {European Cytokine Network},
VOLUME = {31},
YEAR = {2020},
NUMBER = {1},
PAGES = {18--31},
URL = {http://www.techscience.com/ECN/v31n1/65376},
ISSN = {1952-4005},
ABSTRACT = {Special hormonal and immunological changes are required for normal pregnancy continuation.
To escape from rejection by the maternal immune system, pregnancy needs an optimum environment with the
integration and the balance of immune factors. As an immunologically unique site that permits allogenic fetus to be
tolerated by mother, the maternal–fetal interface has a vital role. Microorganisms may trigger innate
immune responses at the maternal–fetal interface and this may have a significant impact on the success of
pregnancy. While the presence of inflammatory markers are slightly increased in healthy pregnancies, their
significant increase in preeclampsia suggests that the balance between the inflammatory and antiinflammatory
mechanisms may be disrupted by a shift towards inflammation. Based on these immunological observations, we
aimed to review the literature for the link between the inflammatory response and preeclampsia since its etiology has
not yet been clarified.},
DOI = {10.1684/ecn.2020.0443}
}