TY  - EJOU
AU  - Zhang, Fu 
AU  - Lin, Miao 
AU  - Jiang, Yuancong 
AU  - Zhou, Fangjian 

TI  - The role of IL-33 in immunotherapy for breast cancer: targets and  signalling pathways
T2  - European Cytokine Network

PY  - 2025
VL  - 36
IS  - 1
SN  - 1952-4005

AB  - Interleukin-33 (IL-33), a key member of the IL-1 family, plays a significant role in inflammation and cancer. Its classic receptors, ST2 and IL-1 receptor accessory protein (IL-1RAcP), are predominantly expressed in immune cells such as T helper 2 (Th2) cells and mast cells. Recent studies have highlighted the involvement of IL-33 in breast cancer, demonstrating its ability to exert dual functional effects by modulating both innate and adaptive immune responses within the tumour microenvironment. However, the precise molecular mechanisms linking IL-33 to breast cancer pathogenesis and its potential as a target for molecularly targeted therapies remain incompletely understood. This review aims to provide a comprehensive summary of the current understanding of IL-33 in breast cancer immunotherapy.
KW  - Breast cancer; IL-33; Cytokine; Immunotherapy; Signalling pathways

DO  - 10.1684/ecn.2025.0500