TY - EJOU AU - Wang, Tianran AU - Wang, Yiran AU - Liu, Wenwen AU - Yan, Chenyu AU - Zhang, Ning AU - Huang, Yangxin AU - Wang, Sijiu AU - Liang, Wannian TI - The Association between eHealth Literacy and Depression among Young and Middle-Aged Adults: Mediations of Lifestyle Behaviors T2 - International Journal of Mental Health Promotion PY - VL - IS - SN - 2049-8543 AB - Background: Young and middle-aged adults are susceptible to depression, which may impose health and economic burdens on both individuals and society. eHealth literacy is the ability for individuals to obtain health information through digital channels, which may be beneficial to their mental health. This study aims to investigate the association between eHealth literacy and depression, as well as the mediating roles of lifestyle behaviors. Methods: The study adopted a cross-sectional survey to collect data from 1280 young and middle-aged participants (Meanage = 39.55 years, 56.72% females) in China. The Chinese version of the eHealth Literacy Scale (eHEALS) and the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) were used to measure eHealth literacy and depression, respectively. Correlation analysis and ordinary least squares regression were conducted to analyze the data. A parallel-mediation model was established to examine the mediating roles of four lifestyle behaviors: smoking, alcohol consumption, sleeping, and exercising. Results: The results showed that eHealth literacy was significantly negatively associated with depression among young and middle-aged adults in China (β = −0.294, 95%CI [−0.330, −0.258], p < 0.001). In addition, the results statistically suggest the mediating roles of smoking (β = −0.010, 95%CI [−0.019, −0.002]), alcohol consumption (β = −0.010, 95%CI [−0.021, −0.002]), sleeping (β = −0.017, 95%CI [−0.026, −0.009]), and exercising (β = −0.016, 95%CI [−0.026, −0.007]) in the association between eHealth literacy and depression. Conclusions: These results suggest that higher levels of eHealth literacy are associated with lower levels of depression, indicating that eHealth literacy could be beneficial to mental health. Healthy lifestyle behaviors in terms of smoking, alcohol consumption, sleeping, and exercising may be mediators in the association. KW - eHealth literacy; depression; lifestyle behavior; smoking; alcohol consumption; sleeping; exercising DO - 10.32604/ijmhp.2026.084709