TY - EJOU AU - Sinha, Anurag AU - Halder, Pranto AU - Pandey, Aditya AU - Shukla, Avi Mohan Kumar AU - Kumar, Shravan AU - Rastogi, Ashutosh AU - Chowdhury, Asima Akter AU - Rai, Suryansh AU - Singh, Sagar TI - Optimizing Capsule Endoscopy via (SHAP) Perturbations and Optimal Data Distribution for Pancreatic Disease Classification T2 - Journal of Intelligent Medicine and Healthcare PY - 2026 VL - 4 IS - 1 SN - 2837-634X AB - Accurate classification of pancreatic endocrinogenesis-related abnormalities in capsule endoscopy images remains challenging because of class imbalance, high intra-class variability, and limited annotated data. This study proposes an optimal data distribution framework based on Local Interpretable Model-Agnostic Explanations (LIME) and SHapley Additive exPlanations (SHAP) perturbations to enhance automated classification performance. The workflow combines perturbation-guided data augmentation, feature-importance analysis, and deep-learning classifiers, including convolutional neural networks (CNNs), U-Net, and You Only Look Once (YOLO). The approach is evaluated on the Kvasir-CapsuleSeg dataset using accuracy, macro F1-score, balanced area under the receiver operating characteristic curve (AUC), and confusion-matrix analysis. Results indicate that perturbation-guided augmentation improves robustness and class balance, with consistent gains across models and particularly strong performance for underrepresented classes. These findings suggest that explainability-driven data optimization can improve automated capsule endoscopy analysis and support more interpretable pancreatic disease classification. KW - Optimal data distribution; local interpretable model-agnostic explanations; SHapley Additive exPlanations; pancreatic disease classification; capsule endoscopy; explainable artificial intelligence; image analysis DO - 10.32604/jimh.2026.075373