TY  - EJOU
AU  - Wang, Rui 
AU  - Shi, Fangyu 
AU  - Zhang, Bing 
AU  - Wang, Tiejun 

TI  - Mitochondrial Metabolic-Signaling Hub in Placenta Accreta Spectrum: From Pathological Reprogramming to Precision Intervention
T2  - BIOCELL

PY  - 
VL  - 
IS  - 
SN  - 1667-5746

AB  - Placenta accreta spectrum (PAS) is a severe obstetric complication characterized by pathologically deep trophoblast invasion. Current clinical management relies heavily on reactive surgical interventions due to a lack of early predictive biomarkers and targeted therapies. This review proposes that the mitochondrion serves as the central metabolic-signaling hub driving PAS progression. We systematically analyze how mitochondrial metabolic reprogramming—specifically a Warburg-like shift toward glycolysis—and dysregulated quality control mechanisms promote maladaptive trophoblast phenotypic reprogramming. Central to this process is the “PAS-mitochondria-derived reactive oxygen species (MitoROS)” axis, where MitoROS species act as persistent signal amplifiers promoting epithelial-mesenchymal transition, apoptosis resistance, and impaired vascular remodeling. Furthermore, we explore the crosstalk between mitochondrial dysfunction and the decidual immune microenvironment. By evaluating the potential of cell-free mitochondrial DNA as a circulating biomarker and discussing the prospects of mitochondria-targeted interventions (e.g., MitoQ, SS-31), this synthesis outlines a paradigm shift toward molecular-targeted prevention and precision diagnostics in PAS management.
KW  - Placenta accreta spectrum; mitochondrial metabolism; oxidative stress; trophoblast invasion; targeted antioxidants; biomarkers

DO  - 10.32604/biocell.2026.083727