TY  - EJOU
AU  - Ansari, Shazia 
AU  - Singh, Gursimran 
AU  - Solomon, Jemimol 
AU  - Kaur, Simranpreet 
AU  - Aran, Khadga Raj 

TI  - Short-Chain Fatty Acids and Related Postbiotic Mediators in Neurodegenerative Diseases
T2  - BIOCELL

PY  - 
VL  - 
IS  - 
SN  - 1667-5746

AB  - Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s Disease (PD), and Multiple sclerosis (MS) represent a growing global health burden characterized by progressive neuronal loss, chronic neuroinflammation, immune dysregulation, and metabolic dysfunction. Increasing evidence highlights the gut-brain-immune axis as a critical regulator of disease susceptibility and progression. Microbiota-derived short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, act as key postbiotic mediators that link intestinal microbial activity to the central nervous system. SCFAS modulates neurodegenerative pathways by regulating glial activation, inflammatory signaling, barrier integrity, and epigenetic and metabolic processes. Altered SCFAS production is consistently associated with neuroinflammation, barrier dysfunction, and disease progression. This review aims to synthesize current mechanistic and translational evidence on SCFAs in neurodegeneration by discussing shared and disease-specific pathways and emerging therapeutic and biomarker applications. Preclinical and early clinical studies suggest that restoring SCFAS signaling may influence disease pathways; its disease-modifying effects in humans remain scarce. These findings support further investigation of SCFAs with precision and microbiota-targeted strategies.
KW  - Neuroinflammation; short-chain fatty acids (SCFAs); gut-brain axis; microbiota dysbiosis; postbiotics

DO  - 10.32604/biocell.2026.082358