TY  - EJOU
AU  - Chen, Yuhua 
AU  - Tan, Xianyi 
AU  - Hu, Yansong 
AU  - Tang, Ye 
AU  - Zhang, Zhengbao 
AU  - Tan, Shengkui 
AU  - Zhu, Xiaonian 

TI  - Research Progress on the Role of Environmental PFAS Exposure in Regulating Mitochondrial Stability
T2  - BIOCELL

PY  - 
VL  - 
IS  - 
SN  - 1667-5746

AB  - Per- and polyfluoroalkyl substances (PFAS) are widely used in industrial processes because of their unique physicochemical properties. Mitochondria—double-membrane organelles present in most eukaryotic cells—govern cellular fate by maintaining structural integrity and bioenergetic homeostasis. Recent studies have demonstrated that PFAS can impair mitochondrial ultrastructure, disrupt energy metabolism, elicit oxidative stress, and trigger mitochondria-dependent apoptotic signaling, potentially contributing to reproductive and developmental disorders, hepatic dysfunction, neurotoxicity, and cardiovascular injury. Therefore, mitochondrial damage may represent one mechanistic pathway contributing to PFAS-associated adverse health outcomes. Here, we summarize current knowledge of the effects of PFAS exposure on mitochondrial architecture and function and delineate the underlying molecular mechanisms, thereby providing a scientific foundation for improving risk assessment and health protection.
KW  - Per- and polyfluoroalkyl substances; mitochondria; environmental exposure

DO  - 10.32604/biocell.2026.084419