@Article{biocell.2026.083171,
AUTHOR = {Dina Tenji, Nina Tomić, Marija Petrović, Marina Jovanović},
TITLE = {Influence of Polyphenol-Dense Residues: Wine Pomace, Coffee and Brewing By-Products, on Nrf2-Mediated Cellular Defense Mechanisms: A Review},
JOURNAL = {BIOCELL},
VOLUME = {},
YEAR = {},
NUMBER = {},
PAGES = {{pages}},
URL = {http://www.techscience.com/biocell/online/detail/27499},
ISSN = {1667-5746},
ABSTRACT = {The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a central regulator of cellular defense mechanisms. It coordinates antioxidant responses, redox homeostasis, inflammation control, mitochondrial function, intracellular iron dynamics, glucose metabolism, lipid metabolism, and proteostasis. Dietary polyphenols can effectively modulate Nrf2 by directly activating the Kelch-like ECH-associated protein 1 (Keap1)-Nrf2-antioxidant response elements (ARE) pathway and by indirectly influencing upstream kinases, epigenetic processes, and metabolites produced by the gut microbiota. By-products, generated in large quantities by the beverage industries, represent an abundant yet underexploited source of polyphenol-rich bioactive compounds. This narrative review critically summarizes current knowledge on molecular mechanisms of Nrf2 signaling, examines the role of dietary polyphenols as Nrf2-linked senotherapeutic agents, and reviews evidence supporting the Nrf2-modulating potential of major categories of polyphenol-rich by-products, coffee by-products (pulp, husk, silver skin, spent coffee ground), wine pomace, and brewing by-products (brewer’s spent grain, brewer’s spent yeast). Finally, key limitations, safety considerations, and research gaps for future investigations have been addressed. Polyphenol-rich agri-food by-products represent a promising tool for modulating endogenous stress-response pathways associated with longevity and may serve as sustainable Nrf2-targeted nutritional interventions, although challenges such as limited bioavailability remain.},
DOI = {10.32604/biocell.2026.083171}
}