@Article{biocell.2002.26.225,
AUTHOR = {ALICIA I. WEYERS, LAURA I. UGNIA, HUGO GARCÍA OVANDO, NORA B. GORLA*},
TITLE = {Ciprofloxacin increases hepatic and renal lipid hydroperoxides levels in mice},
JOURNAL = {BIOCELL},
VOLUME = {26},
YEAR = {2002},
NUMBER = {2},
PAGES = {225--228},
URL = {http://www.techscience.com/biocell/v26n2/34008},
ISSN = {1667-5746},
ABSTRACT = {Ciprofloxacin (CFX) is an effective and relatively safe antimicrobial used in a variety of human infections. However, adverse drug reactions and positive results in genotoxic tests are reported. <br/>
In order to understand the possible pathophysiological mechanisms of the toxic effects informed for CFX, lipid hydroperoxides (LOOH) -oxidative mediators of peroxidation- were quantified in liver and kidney of mice, after 15 to 360 minutes of the ciprofloxacin administration at doses of 10 mg/ Kg or 100 mg/ Kg by ip route. The peroxidation in the lipid fraction was evaluated by measuring the amount of hydroperoxides through the oxidation of 1- naphthyldiphenylphospine into its oxide and further quantification by high performance liquid chromatography. <br/>
The initial content of lipid hydroperoxides (nmol/g tissue) was 253 ± 3 in kidney and 143 ± 12 in liver. CFX induced the maximal variation to 728 ± 101 in kidney (P < 0.05) and 315 ± 31 in liver (P < 0.01), after 15 min of 100 mg/ Kg single dose. The variation in the LOOH levels was significant in kidney with both doses used and in liver after 100 mg/ Kg until 60 min after the CFX administration, and then gradually fell to natural levels. <br/>
The results demonstrated the effect of CFX on lipid oxidation, an indicator of oxidative effect. A natural protective capacity against this oxidation, more efficient in liver than in kidney, was observed.},
DOI = {10.32604/biocell.2002.26.225}
}