@Article{biocell.2003.27.213,
AUTHOR = {Lidia M. Lopez*, Marta Dubin**, Patricia H. Carrizo**, Mario H. Burgos***, Amanda Pellegrino De Iraldi*, Andrés O. M. Stoppani**},
TITLE = {Apoptogenic effect of the lipophilic <i>o</i>-naphthoquinone CG 10-248 on rat hepatocytes: light and electron microscopy studies},
JOURNAL = {BIOCELL},
VOLUME = {27},
YEAR = {2003},
NUMBER = {2},
PAGES = {213--224},
URL = {http://www.techscience.com/biocell/v27n2/36293},
ISSN = {1667-5746},
ABSTRACT = {CG 10-248 (3,4-dihydro-2,2-dimethyl-9-chloro-2H-naphtho[1,2b]pyran- 5,6-dione; CG-NQ), a β-lapachone analogue, modified the ultrastructure of rat hepatocytes, as demonstrated by light and electron microscopy. After 4 h incubation with 100 µM CG-NQ, the following effects were observed: (a) nuclear chromatin condensation; (b) chromatin fragmentation; (c) displacement of mitochondria, concentrated around the nucleus; (d) disruption or expansion of mitochondrial outer or inner membranes, respectively; (e) displacement and alteration of endoplasmic reticulum (rough and smooth); (f) decrease of microvilli; (g) blebbing of plasma membrane and production of apoptotic bodies formed by folding of plasma membrane fragments around mitochondria or peroxysomes; and (h) production of hydrogen peroxide. Expression of such effects varied according to hepatocyte samples and taken together strongly support an apoptotic action of CG-NQ dependent on “reactive oxygen species”. },
DOI = {10.32604/biocell.2003.27.213}
}