@Article{biocell.2004.28.031,
AUTHOR = {MARÍA DE LOS ANGELES ALVAREZ, VALERIA E. P. ZARELLI, NORA B.PAPPANO, NORA B. DEBATTISTA},
TITLE = {Bacteriostatic action of synthetic polyhydroxylated chalcones against <i>Escherichia coli</i>},
JOURNAL = {BIOCELL},
VOLUME = {28},
YEAR = {2004},
NUMBER = {1},
PAGES = {31--34},
URL = {http://www.techscience.com/biocell/v28n1/37642},
ISSN = {1667-5746},
ABSTRACT = {In previous work the bacteriostatic action of trihydroxylated chalcones against <i>Staphylococcus aureus</i> ATCC 25 923 was investigated. In this work the action of 2´, 4´, 2-(OH)<sub>3</sub> -chalcone, 2´, 4´, 3-(OH)<sub>3<sup>-</sup></sub> chalcone and 2´, 4´, 4-(OH)<sub>3</sub> –chalcone against <i>Escherichia coli</i> ATCC 25 922 was evaluated. Growth kinetic curves of <i>E.coli</i> were made in nutritive broth added with increasing drug concentrations. The specific growth rates of the microorganisms were calculated by a kinetic turbidimetric method, which was previously probed and the minimal inhibitory concentrations (MIC´s) were evaluated by a mechanism of action proposed. The MICs of 2´, 4´, 3-(OH)<sub>3</sub> -chalcone and 2´, 4´, 2-(OH)<sub>3</sub> -chalcone were 46 µg/ml and 122 µg/ml, respectively. The 2´, 4´, 4-(OH)<sub>3</sub> –chalcone was inactive. The MIC value of 2´, 4´, 3-(OH)<sub>3</sub>-chalcone (46 µg/ml), more active than 2´, 3-(OH)<sub>2</sub>-chalcone (72.2 µg/ml) may be due to the introduction of an electron donating group (-OH) at position 4´ in the aromatic A- ring, which activates the region that includes the 2´-hydroxyl neighbur group and the α,β- unsaturated carbonyl group.},
DOI = {10.32604/biocell.2004.28.031}
}