@Article{biocell.2006.30.009,
AUTHOR = {R. SEHGAL, S. ROY,  V.L. KUMAR*},
TITLE = {Evaluation of cytotoxic potential of latex of <i>Calotropis procera</i> and Podophyllotoxin in <i>Allum cepa</i> root model},
JOURNAL = {BIOCELL},
VOLUME = {30},
YEAR = {2006},
NUMBER = {1},
PAGES = {9--13},
URL = {http://www.techscience.com/biocell/v30n1/37682},
ISSN = {1667-5746},
ABSTRACT = {In the present study we have utilized the <i>Allium cepa</i> root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of <i>Calotropis procera</i> (DL) and podophyllotoxin. Standard cytotoxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations.},
DOI = {10.32604/biocell.2006.30.009}
}