TY  - EJOU
AU  - KUMAR*, R. SEHGAL, S. ROY,  V.L. 

TI  - Evaluation of cytotoxic potential of latex of <i>Calotropis procera</i> and Podophyllotoxin in <i>Allum cepa</i> root model
T2  - BIOCELL

PY  - 2006
VL  - 30
IS  - 1
SN  - 1667-5746

AB  - In the present study we have utilized the <i>Allium cepa</i> root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of <i>Calotropis procera</i> (DL) and podophyllotoxin. Standard cytotoxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations.
KW  - <i>Calotropis procera</i>
KW  -  Podophyllotoxin
KW  -  cyclophosphamide
KW  -  cytotoxic
KW  -  <i>Allium cepa</i>

DO  - 10.32604/biocell.2006.30.009