@Article{biocell.2006.30.295,
AUTHOR = {MARLI APARECIDA DOS SANTOS PEREIRA, MARIA CLAÚDIA BAGATIN, JACQUELINE NELISIS ZANONI},
TITLE = {Effects of the ascorbic acid supplementation on NADH-diaphorase myenteric neurons in the duodenum of diabetic rats},
JOURNAL = {BIOCELL},
VOLUME = {30},
YEAR = {2006},
NUMBER = {2},
PAGES = {295--300},
URL = {http://www.techscience.com/biocell/v30n2/37694},
ISSN = {1667-5746},
ABSTRACT = {We assessed the ascorbic acid (AA) supplementation on the myenteric neurons in the duodenum of rats. Fifteen rats with 90 days of age were divided into three groups: control (C), diabetics (D) and ascorbic acid treated diabetics (DA). After 120 days of daily treatment with AA, the duodenum was submitted to the NADH-diaphorase (NADH-d) histochemical technique, which allowed us to evaluate the neuronal density in an area of 8.96 mm<sup>2</sup> for each duodenum, and also to measure the cellular profile area of 500 neurons <i>per</i> group. The supplementation promoted an increase on AA levels. The neuronal density (p <0.05) was higher in the group DA when compared to group D. There were no significant differences in the neuronal areas, when we compared groups C (204 ± 16.5) and D (146.3 ± 35.84) to groups D and DA (184.5 ± 5.6) (p> 0.05). The AA-supplementation avoided the density reduction of the NADHd myenteric neurons in the duodenum of diabetic rats.},
DOI = {10.32604/biocell.2006.30.295}
}