TY  - EJOU
AU  - QI, BING 
AU  - ZHENG, XINMING 
AU  - LI, WENYONG 
AU  - WEI, QINGXIN 
AU  - CHEN, QINGXUAN 

TI  - Cloning and analysis of IFRG (interferon responsive gene) in rabbit oocytes and preimplantation embryos
T2  - BIOCELL

PY  - 2007
VL  - 31
IS  - 2
SN  - 1667-5746

AB  - Although there is more evidence that shows that IFNs (interferons) plays a very important role
in the early development of the embryo, the mechanism of IFNs is still unclear. Our study showed that IFRG
is expressed from oocytes- through to the preimplantation embryo in rabbits. This finding provides some
clues for better understanding the role of IFNs in the development of the embryo. The full length of rabbit
IFRG cDNA (Accession No. AJ584672), with a 2794bp encoding 131 amino acid sequence, was cloned
IFRG expression can be detected in 8 different tissues: ovary, heart, lung, liver, kidney, spleen, cerebra, and
the 18-day whole-body embryo. Whole-mount <i>in situ</i> hybridization showed that IFRG was highly expressed
in the inner-cell mass of rabbit blastula. IFRG may play an important role in embryo development and tissue
differentiation.
KW  - preimplantation embryo development
KW  -  Interferon α responsive gene
KW  -  whole mount <i>in situ</i> hybridization

DO  - 10.32604/biocell.2007.31.199