TY  - EJOU
AU  - KAILONG, LI 
AU  - XIAOLAN, DU 
AU  - YANI, HE 
AU  - LIN, ZHAO 
AU  - JVRONG, YANG 
AU  - RUIHUA, SONG 
AU  - LIN, CHEN 

TI  - p53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury
T2  - BIOCELL

PY  - 2007
VL  - 31
IS  - 2
SN  - 1667-5746

AB  - <b>Objective:</b> To investigate the course of tubular cell senescence and expressions of p53, p21,
and Rb during the late phase of ischemia/reperfusion (IRI) in the kidney, and assess the effects of the p53-Rb
pathway on tubular cell senescence. <b>Methods:</b> Experimental models of unilateral renal IRI were used in
p53(+/+) and p53(-/-) mice. Histological changes at the tubular level, progress of cell senescence, and the
expression of Rb, p21, and/or p53 proteins in tubular cells were studied at different moments in time after
IRI. <b>Results:</b> Chronic tubulointerstitial fibrosis was much more severe and widely distributed in IRI kidneys
of p53(+/+) mice in later stages than in earlier stages. Senescent tubular cells were significantly increased at
3 and 6 months after IRI. In contrast, in contralateral kidneys of p53(+/+) mice and in both kidneys of p53(-/-) mice, almost no senescent cells were observed at 1 and 3 months after IRI, and only a few senescent cells
were detected in IRI kidneys of p53(-/-) mice at 6 months. In mice of both genotypes, cell senescence was
correlated with the expression levels of p53, p21, and Rb proteins. <b>Conclusion:</b> The IRI accelerated tubular
cell senescence is presumed to be one of the mechanisms of the “long-term effect” of IRI. Furthermore, the
activation of p53-Rb signaling pathway may play a vital role in tubular cell senescence induced by IRI.

KW  - cell senescence
KW  -  cell cycle regulatory protein
KW  -  ischemia/reperfusion injury
KW  -  kidney

DO  - 10.32604/biocell.2007.31.213