@Article{biocell.2008.32.195,
AUTHOR = {RAQUEL ALVES DOS SANTOS, TERESINHA ROSA CABRAL, ISABEL ROSA CABRAL, LUSÂNIA MARIA GREGGI ANTUNES, CRISTIANE PONTES ANDRADE, PLÍNIO CERQUEIRA DOS SANTOS CARDOSO, MARCELO DE OLIVEIRA BAHIA, CLAUDIA PESSOA, JOSÉ LUIS MARTINS DO NASCIMENTO, ROMMEL RODRÍGUEZ BURBANO, CATARINA SATIE TAKAHASHI},
TITLE = {Genotoxic effect of <i>Physalis angulata</i> L. (Solanaceae) extract on human lymphocytes treated <i>in vitro</i>},
JOURNAL = {BIOCELL},
VOLUME = {32},
YEAR = {2008},
NUMBER = {2},
PAGES = {195--200},
URL = {http://www.techscience.com/biocell/v32n2/37739},
ISSN = {1667-5746},
ABSTRACT = {<i>Physalis angulata</i> L (Solanaceae) is a medicinal plant from North of Brazil, whose different extracts and infusions are commonly used in the popular medicine for the treatment of malaria, asthma, hepatitis, dermatitis and rheumatism. However, the genotoxic effects of <i>P. angulata</i> on human cells is not well known. The main purpose of the present study was to evaluate the <i>in vitro</i> genotoxic effects of aqueous extract of <i>P. angulata</i> using the comet assay and the micronucleus assay in human lymphocytes provided from 6 healthy donors. Treatments with <i>P. angulata</i> extracts were performed <i>in vitro</i> in order to access the extent of DNA damage. The comet assay has shown that treatments with <i>P. angulata</i> at 0.5, 1.0, 2.0, 3.0 and 6.0 μg/mL in culture medium were genotoxic. Lymphocytes treated with <i>P. angulata</i> at the concentrations of 3.0 and 6.0 μg/mL in culture medium showed a statistically significant increase in the frequency of micronucleus (p<0.05), however, the cytokinesis blocked proliferation index (CBPI) was not decreased after <i>P. angulata</i> treatment. In conclusion, the present work demonstrated the genotoxic effects of <i>P. angulata</i> extract on human lymphocytes <i>in vitro</i>.},
DOI = {10.32604/biocell.2008.32.195}
}