@Article{biocell.2008.32.251,
AUTHOR = {SILVIA S. BORKOSKY, HITOSHI NAGATSUKA, YORIHISA ORITA, HIDETSUGU TSUJIGIWA, JUNKO YOSHINOBU, MEHMET GUNDUZ, ANDREA P. RODRIGUEZ, LILIANA R. MISSANA, KAZUNORI NISHIZAKI, NORIYUKI NAGAI},
TITLE = {Sequential expressions of <i>Notch1, Jagged2</i> and <i>Math1</i> in molar tooth germ of mouse},
JOURNAL = {BIOCELL},
VOLUME = {32},
YEAR = {2008},
NUMBER = {3},
PAGES = {251--257},
URL = {http://www.techscience.com/biocell/v32n3/37747},
ISSN = {1667-5746},
ABSTRACT = {The Notch signaling pathway is an evolutionary conserved mechanism that plays an important role in cell-cell communication and cell fate in a wide range of tissues. The mammalian family of Notch receptors consists of 4 members: Notch1/2/3/4. The Notch ligand family consists of 5 members: Delta1/3/4 and Jagged1/2. <i>Math1</i> encodes a murine basic helix-loop-helix (bHLH) transcription factor that acts as positive regulator of cell differentiation. Recently, links between <i>Notch</i> and <i>Math1</i> pathways were demonstrated in various tissues. Expression of <i>Notch1, Jagged2</i> and <i>Math1</i> were analyzed in the mouse molar tooth germ during embryonic stage (E) 13 and E15 and during postnatal stage (PN) 1, PN3, PN5, PN10 and PN14 by using in situ hybridization. Positive <i>Notch1</i> expression was found at the tooth bud during embryonic stages, but its expression was absent from the basal cells in contact with the dental mesenchyme. <i>Jagged2</i> and <i>Math1</i> were strongly expressed in differentiated ameloblasts and odontoblasts and <i>Math1</i> strong expression was even maintained until PN14 stage. <i>Math1</i> showed the strongest expression. Our results suggest that the Notch1 signaling pathway through Jagged2 could be importantly related to Math1, directing the process of odontogenesis toward cell differentiation.},
DOI = {10.32604/biocell.2008.32.251}
}