@Article{biocell.2009.33.107,
AUTHOR = {CHANG SEOK LEE, YONG JAE SHIN, CHEOLHEE WON, YUN-SONG LEE, CHUNG-GYU PARK, SANG-KYU YE, MYUNG-HEE CHUNG},
TITLE = {Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells},
JOURNAL = {BIOCELL},
VOLUME = {33},
YEAR = {2009},
NUMBER = {2},
PAGES = {107--114},
URL = {http://www.techscience.com/biocell/v33n2/37760},
ISSN = {1667-5746},
ABSTRACT = {Cyclooxygenase-2 (COX-2) is a key inflammatory response molecule, and associated with many immune functions of monocytes/macrophages. Particularly, interferon gamma (IFNγ)-induced COX-2 expression appears in inflammatory conditions such as viral infection and autoimmune diseases. Recently, statins have been reported to show variable effects on COX-2 expression, and on their cell and species type dependences. Based on the above description, we compared the effect of simvastatin on IFNγ-induced COX2 expression in human monocytes versus murine macrophages. In a result, we found that simvastatin suppresses IFNγ-induced COX-2 expression in human THP-1 monocytes, but rather, potentiates IFNγ-induced COX-2 expression in murine RAW264.7 macrophages. However, signal transducer and activator of transcription 1/3 (STAT1/3), known as a transcription factor on COX-2 expression, is inactivated by simvastatin in both cells. Our findings showed that simvastatin is likely to suppress IFNγ-induced COX-2 expression by inhibiting STAT1/3 activation in human THP-1 cells, but not in murine RAW264.7 cells. Thus, we concluded that IFNγ-induced COX-2 expression is differently regulated by simvastatin depending on species specific mechanism.},
DOI = {10.32604/biocell.2009.33.107}
}