TY  - EJOU
AU  - LEE, CHANG SEOK 
AU  - SHIN, YONG JAE 
AU  - WON, CHEOLHEE 
AU  - LEE, YUN-SONG 
AU  - PARK, CHUNG-GYU 
AU  - YE, SANG-KYU 
AU  - CHUNG, MYUNG-HEE 

TI  - Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells
T2  - BIOCELL

PY  - 2009
VL  - 33
IS  - 2
SN  - 1667-5746

AB  - Cyclooxygenase-2 (COX-2) is a key inflammatory response molecule, and associated with many immune functions of monocytes/macrophages. Particularly, interferon gamma (IFNγ)-induced COX-2 expression appears in inflammatory conditions such as viral infection and autoimmune diseases. Recently, statins have been reported to show variable effects on COX-2 expression, and on their cell and species type dependences. Based on the above description, we compared the effect of simvastatin on IFNγ-induced COX2 expression in human monocytes versus murine macrophages. In a result, we found that simvastatin suppresses IFNγ-induced COX-2 expression in human THP-1 monocytes, but rather, potentiates IFNγ-induced COX-2 expression in murine RAW264.7 macrophages. However, signal transducer and activator of transcription 1/3 (STAT1/3), known as a transcription factor on COX-2 expression, is inactivated by simvastatin in both cells. Our findings showed that simvastatin is likely to suppress IFNγ-induced COX-2 expression by inhibiting STAT1/3 activation in human THP-1 cells, but not in murine RAW264.7 cells. Thus, we concluded that IFNγ-induced COX-2 expression is differently regulated by simvastatin depending on species specific mechanism.
KW  - monocyte
KW  -  macrophage
KW  -  INFγ
KW  -  STAT1/3
KW  -  SOCS1/3

DO  - 10.32604/biocell.2009.33.107