@Article{biocell.2009.33.187,
AUTHOR = {VIRGINIA VILLALOBOS, ERNESTO BONILLA, ALAN CASTELLANO, ERNESTO NOVO, RALPH CASPERSEN, DEBORA GIRALDOTH,  SHIRLEY MEDINA-LEENDERTZ},
TITLE = {Ultrastructural changes of the olfactory bulb in manganesetreated mice},
JOURNAL = {BIOCELL},
VOLUME = {33},
YEAR = {2009},
NUMBER = {3},
PAGES = {187--197},
URL = {http://www.techscience.com/biocell/v33n3/37770},
ISSN = {1667-5746},
ABSTRACT = {The effect of manganese toxicity on the ultrastructure of the olfactory bulb was evaluated. Male albino mice were injected intraperitoneally with MnCl<sub>2</sub> (5 mg/Kg/day) five days per week during nine weeks. The control group received NaCl (0.9%). The olfactory bulbs of five mice from each group were processed for transmission electron microscopy after 2, 4, 6 and 9 weeks of manganese treatment. On week 2, some disorganization of the myelin sheaths was observed. After 4 weeks, degenerated neurons with dilated cisternae of rough endoplasmic reticulum and swollen mitochondria appeared. A certain degree of gliosis with a predominance of astrocytes with swollen mitochondria, disorganization of the endomembrane system, dilation of the perinuclear cisternae and irregularly shaped nuclei with abnormal chromatin distribution were observed after 6 weeks. Some glial cells showed disorganization of the Golgi apparatus. On week 9, an increase in the number of astrocytes, whose mitochondrial cristae were partially or totally erased, and a dilation of the rough endoplasmic reticulum were found. Neurons appear degenerated, with swollen mitochondria and a vacuolated, electron dense cytoplasm. These changes seem to indicate that the olfactory bulb is sensitive to the toxic effects of manganese.},
DOI = {10.32604/biocell.2009.33.187}
}