@Article{biocell.2010.34.091,
AUTHOR = {LIPING ZHOU*, XIAOLIN GUO, JING BA, LIANSHUANG ZHA},
TITLE = {Brief Note: CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity},
JOURNAL = {BIOCELL},
VOLUME = {34},
YEAR = {2010},
NUMBER = {2},
PAGES = {91--94},
URL = {http://www.techscience.com/biocell/v34n2/37782},
ISSN = {1667-5746},
ABSTRACT = {CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.},
DOI = {10.32604/biocell.2010.34.091}
}