TY - EJOU AU - ZHA, LIPING ZHOU*, XIAOLIN GUO, JING BA, LIANSHUANG TI - Brief Note: CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity T2 - BIOCELL PY - 2010 VL - 34 IS - 2 SN - 1667-5746 AB - CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration. KW - cell migration KW - lamellipodia formation KW - uropod formation KW - hyaluronic acid DO - 10.32604/biocell.2010.34.091