@Article{biocell.2013.37.011,
AUTHOR = {LOKMAN VARISLI},
TITLE = {Meta-analysis of the cell cycle related <i>C12orf48</i>},
JOURNAL = {BIOCELL},
VOLUME = {37},
YEAR = {2013},
NUMBER = {1},
PAGES = {11--16},
URL = {http://www.techscience.com/biocell/v37n1/35104},
ISSN = {1667-5746},
ABSTRACT = { The cell cycle is a conserved process from yeast to mammals and focuses on mechanisms that
regulate the timing and frequency of DNA replication and cell division. The temporal and spatial expression
of the genes is tightly regulated to ensure accurate replication and transmission of DNA to daughter cells
during the cycle. Although the genes involved in interphase are well studied, most of the genes which are
involved in mitotic events still remain unidentified. Since, the discovery of mitosis related genes is still
incomplete, we performed a co-expression and gene ontology analysis for revealing novel mitosis regulated
genes. In this study, we showed that <i>C12orf48</i> is co-expressed with well-known mitotic genes. Moreover, it is
also co-expressed with the genes that have roles in interphase such as DNA replication. Furthermore, our
results showed that <i>C12orf48</i> is also differentially expressed in various cancers. Therefore, the results presented in this study suggest that <i>C12orf48</i> may be an important molecule for both interphase and mitosis.
Since, the molecules involved in these mechanisms are crucial for proliferation as well as in carcinogenesis,
<i>C12orf48</i> should be considered as a novel cell cycle and carcinogenesis related gene.},
DOI = {10.32604/biocell.2013.37.011}
}