@Article{biocell.2013.37.023,
AUTHOR = {VIVIANE DAL-SOUTO FRESCURA, ANDRIELLE WOUTERS KUHN, HAYWOOD DAIL LAUGHINGHOUSE IV, JUÇARA TEREZINHA PARANHOS, SOLANGE BOSIO TEDESCO},
TITLE = {Post-treatment with plant extracts used in Brazilian folk medicine caused a partial reversal of the antiproliferative effect of glyphosate in the<i> Allium cepa </i> test},
JOURNAL = {BIOCELL},
VOLUME = {37},
YEAR = {2013},
NUMBER = {2},
PAGES = {23--28},
URL = {http://www.techscience.com/biocell/v37n2/35106},
ISSN = {1667-5746},
ABSTRACT = { Species of the genus <i>Psychotria</i> are used for multiple purposes in Brazilian folk medicine, either
as water infusions, baths or poultices. This study was aimed to evaluate the genotoxic and antiproliferative
effects of infusions of <i>Psychotria brachypoda</i> and <i>P. birotula</i> on the <i>Allium cepa</i> test. Exposure to distilled
water was used as a negative control, while exposure to glyphosate was used as a positive control. The interaction of extracts (as a post-treatment) with the effects of glyphosate was also studied. Results showed that
glyphosate and the extracts of both <i>P. brachypoda</i> and <i>P. birotula</i> reduced the mitotic index as compared with
the negative control (distilled water). Surprisingly, however, both extracts from <i> P. brachypoda</i>  and <i>P. birotula</i> 
caused a partial reversal of the antiproliferative effect of glyphosate when used as a post-treatment. Glyphosate also induced the highest number of cells with chromosomal alterations, which was followed by that of
<i>P. birotula</i>  extracts. However, the extracts from <i>P. brachypoda</i>  did not show any signifi cant genotoxic effect.
Post-treatment of glyphosate-treated samples with distilled water allowed a partial recovery of the genotoxic
effect of glyphosate, and some of the Psychotria extracts also did so. Notably, post-treatment of glyphosatetreated samples with P. brachypoda extracts induced a statistically signifi cant apoptotic effect. It is concluded
that <i>P. brachypoda</i>  extracts show antiproliferative effects and are not genotoxic, while extracts of <i>P. birotula</i> 
show a less potent antiproliferative effect and may induce chromosomal abnormalities. The finding of a partial
reversion of the effects of glyphosate by a post-treatment with extracts from both plants should be followed up.},
DOI = {10.32604/biocell.2013.37.023}
}