@Article{biocell.2013.37.071,
AUTHOR = {Tamilselvan SUBRAMANI, Suresh RAO, Kamatchiammal SENTHILKUMAR, Soundararajan PERIASAMY, Noorjahan Banu ALITHEEN},
TITLE = {Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts},
JOURNAL = {BIOCELL},
VOLUME = {37},
YEAR = {2013},
NUMBER = {3},
PAGES = {71--76},
URL = {http://www.techscience.com/biocell/v37n3/37817},
ISSN = {1667-5746},
ABSTRACT = {The present study demonstrates that the expression of c-Jun and c-Fos are elevated in gingival fibroblast cells treated with angiotensin II and cyclosporine. The healthy human gingival tissues were collected and gingival fibroblasts were isolated and cultured. We used RT-PCR and Western blot analysis to identify the expression of c-Jun and c-Fos in cyclosporine and angiotensin II treated human gingival fibroblast cells. We found that angiotensin II in combination with cyclosporine induces c-Jun and c-Fos expressions significantly; however, the angiotensin II antagonist losartan inhibits the expression of c-Jun and c-Fos (p < 0.01). The data suggest that angiotensin II in combination with cyclosporine modulates the expression of c-Jun and c-Fos in human gingival fibroblast cells.},
DOI = {10.32604/biocell.2013.37.071}
}