@Article{biocell.2015.39.001,
AUTHOR = {Anna PAŃCZYSZYN, Anna KROP-WATOREK, Maciej WIECZOREK},
TITLE = {Carcinoembryonic antigen inhibits neutrophil activation by N-formyl-methionyl-leucyl-phenylalanine},
JOURNAL = {BIOCELL},
VOLUME = {39},
YEAR = {2015},
NUMBER = {2-3},
PAGES = {1--4},
URL = {http://www.techscience.com/biocell/v39n2-3/34050},
ISSN = {1667-5746},
ABSTRACT = {Carcinoembryonic antigen (CEA) is a surface glycoprotein expressed in human epithelial cells
and is released from their surface, especially during colorectal cancer. Frequently, colorectal cancer is accompanied by inflammation, where tumor-infiltrating neutrophils play an important role. CEA was also found to be
a strong chemotactic agent for neutrophils. The purpose of this study was to find out if CEA can enhance neutrophil priming and activation. Primed neutrophils were activated by N-formyl-methionyl-leucyl-phenylalanine
(formyl-MLP) and the resulting oxidative burst was measured luminometrically. Unexpectedly, in vitro priming
of neutrophils by CEA, alone or preceded by LPS, inhibited subsequent activation of these cells by formyl-MLP.
CEA may have anti-inflammatory properties <i>in vivo</i>. },
DOI = {10.32604/biocell.2015.39.001}
}