TY  - EJOU
AU  - PAŃCZYSZYN, Anna 
AU  - KROP-WATOREK, Anna 
AU  - WIECZOREK, Maciej 

TI  - Carcinoembryonic antigen inhibits neutrophil activation by N-formyl-methionyl-leucyl-phenylalanine
T2  - BIOCELL

PY  - 2015
VL  - 39
IS  - 2-3
SN  - 1667-5746

AB  - Carcinoembryonic antigen (CEA) is a surface glycoprotein expressed in human epithelial cells
and is released from their surface, especially during colorectal cancer. Frequently, colorectal cancer is accompanied by inflammation, where tumor-infiltrating neutrophils play an important role. CEA was also found to be
a strong chemotactic agent for neutrophils. The purpose of this study was to find out if CEA can enhance neutrophil priming and activation. Primed neutrophils were activated by N-formyl-methionyl-leucyl-phenylalanine
(formyl-MLP) and the resulting oxidative burst was measured luminometrically. Unexpectedly, in vitro priming
of neutrophils by CEA, alone or preceded by LPS, inhibited subsequent activation of these cells by formyl-MLP.
CEA may have anti-inflammatory properties <i>in vivo</i>. 
KW  - CEA
KW  -  oxidative burst
KW  -  formyl-MLP

DO  - 10.32604/biocell.2015.39.001