@Article{biocell.2016.40.011,
AUTHOR = {Juanita BUSTAMANTE, Analía CZERNICZYNIEC, Silvia LORES-ARNAIZ},
TITLE = {Ketamine effect on intracellular and mitochondrial calcium mobilization},
JOURNAL = {BIOCELL},
VOLUME = {40},
YEAR = {2016},
NUMBER = {1},
PAGES = {11--14},
URL = {http://www.techscience.com/biocell/v40n1/33973},
ISSN = {1667-5746},
ABSTRACT = { The suppressive effects of ketamine on intracellular calcium has been reported in a variety of cells
although the mechanisms involved are not well understood. The aim of this work was to evaluate the ketamine
effect on the mitochondrial Ca<sup>2+</sup> accumulation and the cellular Ca<sup>2+</sup> mobilization using FLUO4-AM and flow
cytometry. The results showed that mitochondria from ketamine injected animals presented a lower ability to
retain calcium at concentrations higher than 20 μM, as compared with controls (saline injected animals). In addition, ketamine showed a significant decreased KCl-induced intracellular calcium concentration. KCl increased
calcium influx through cellular depolarization. According to the data presented herein, ketamine presents a
clear inhibitory effect on cytosolic Ca<sup>2+</sup> transport mechanisms, independently from their action on the calcium
channel associated NMDA receptor.},
DOI = {10.32604/biocell.2016.40.011}
}