TY - EJOU
AU - Karadayian, Analia G.
AU - Bustamante, Juanita
AU - Lores-Arnaiz, Silvia
TI - Alcohol hangover: impairments in behavior and bioenergetics in central nervous system
T2 - BIOCELL
PY - 2016
VL - 40
IS - 1
SN - 1667-5746
AB - Alcohol hangover (AH) is defined as the temporary state after alcohol binge-like drinking, starting
when EtOH is absent in plasma. Results from our laboratory have shown behavioral impairments and mitochondrial dysfunction in an experimental model of AH in mice. Our model consisted in a single i.p. injection of EtOH
(3.8 g/kg BW) or saline solution in male and female mice, sacrificing the animals 6 hours after injection. Motor and
affective behavior together with mitochondrial function and free radical production were evaluated in brain cortex
and cerebellum during AH. Results showed that hangover animals exhibited a significant reduction in neuromuscular coordination, motor strength and locomotion together with a loss of gait stability and walking deficiencies.
Moreover, an increment in anxiety-like behavior together with fear-related phenotype and depression signs were
observed. In relation to bioenergetics metabolism, AH induced a reduction in oxygen uptake, inhibition of respiratory complexes, changes in mitochondrial membrane permeability, decrease in transmembrane potential, increase
in O2
•- and H2O2 production and impairment in nitric oxide metabolism. All together our data suggest that the physiopathological state of AH involves behavioral impairments and mitochondrial dysfunction in mouse brain cortex
and cerebellum showing the long lasting effects of acute EtOH exposure in CNS.
KW - alcohol hangover
KW - motor performance
KW - ataxia
KW - mitochondria
KW - free radicals
DO - 10.32604/biocell.2016.40.031